There is a likelihood of a grand power shift away from the ruling African National Congress.   The top leadership of the African National Congress (ANC) starts meeting on Friday in a bid to heal a bitter split in the key region of KwaZulu-Natal that could derail its plans to elect a successor to President Jacob Zuma as party leader in December.

The three-day meeting comes after the High Court annulled the election of Zuma allies as the province’s party leadership because the conference that chose them wasn’t lawfully convened. While the officials who lost the case said they’ll challenge the judgment, the ANC’s national executive committee may overrule them to ensure its December 16-20 national elective conference goes ahead.

Rivalries run especially deep in KwaZulu-Natal, which has the largest number of party members and is Zuma’s home province. The Institute for Security Studies has recorded about 100 political killings in the region since 2013. Nationally, the ANC is in turmoil because of the scandals that have shadowed Zuma during his eight-year presidency and the widening split between supporters of his ex-wife, Nkosazana Dlamini-Zuma, and Deputy President Cyril Ramaphosa, who are the leading candidates to succeed him.

“There will be an attempt at Friday’s meeting to try and consolidate unity within the ANC, but I honestly believe it is too late,” Sethulego Matebesi, a political analyst at the University of the Free State in the central town of Bloemfontein, said by phone. “There is a cancer that has spread too much within the ANC.”

The infighting and the legal challenges in KwaZulu-Natal could foreshadow an even bigger crisis around the December congress, said Ralph Mathekga, a political analyst at the Mapungubwe Institute for Strategic Reflection, a Johannesburg-based research group.

“The elective conference might end up being interdicted – you cannot rule it out,” he said. “The outcome can also be questioned in court, because we have seen this happening at the provincial level and at the regional level. Make no mistake, we might see court challenges around this conference.”

Such an outcome could delay Zuma’s departure as party leader and throw into question who would succeed him to become the ANC’s presidential candidate in 2019. It may also leave Africa’s most-industrialised nation with a leadership vacuum at a time when the economy is forecast to expand less than 1% this year and unemployment is at a 14-year high.

ANC Secretary-General Gwede Mantashe and spokesperson Zizi Kodwa didn’t answer calls to their mobile phones.

“This just brings uncertainty to Zuma,” Mathekga said. “He has got too many challenges on too many fronts at the same time.”

Zuma faces almost daily reports of new details on his friendship with the Gupta family and its alleged influence over his administration which is known locally as “state capture.”

The scandal has swept up global companies such as accountants KPMG and consultancy McKinsey, which have been implicated in facilitating, being party to or turning a blind eye to their deals. Public relations firm Bell Pottinger collapsed after it was found to have mounted a racially divisive campaign while work for the Guptas. Zuma and the Guptas deny wrongdoing.

Zuma has survived two bids to oust him by members of the NEC since November and last month saw off an opposition motion of no confidence in his leadership that was backed by more than two dozen ANC lawmakers in parliament. The party, which came to power in 1994 under Nelson Mandela, suffered its worst electoral showing in municipal elections in August last year, losing control of Pretoria, the capital, and Johannesburg, the financial centre.

Last week, the Supreme Court of Appeals considered an opposition lawsuit aimed at compelling prosecutors to reinstate more than 700 graft charges against Zuma that were dropped just weeks before he became president in 2009. The court reserved its judgment and didn’t say when it will be delivered.

While the case against Zuma is unlikely to take centre stage at the NEC meeting, factionalism and infighting of the type that’s occurring in KwaZulu-Natal will frustrate efforts to unify the 105-year-old party and ensure a smooth succession, according to Roland Henwood, a politics lecturer at the University of Pretoria.

“The problem with the NEC is the level of division, lack of trust that informs what is happening in the ANC,” Henwood said. “It has in a sense paralyzed the ANC, and that paralysis is affecting everything that happens within the party.”